Tuesday, November 21, 2017
Multi-platform ’Omics Analysis of Human Ebola Virus Disease Pathogenesis
Ebola virus disease (EDV) is a well-known and fatal disease in Africa. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus-and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD pathophysiology, the reseachers performed multi-platform 'omics analysis of peripheral blood mono-nuclear cells and plasma from EVD patients. The results indicate that EVD molecular signatures overlap with those of sepsis, imply that pancreatic enzymes contribute to tissue damage in fatal EVD, and suggest that Ebola virus infection may induce aberrant neutrophilis whose activity could explain hallmarks of fatal EVD. Moreover, integrated biomarker prediction identified putative biomarkers from different data platforms that differentiated survivors and fatalities early after infection. In my opinion, this work reveals insight into EVD pathogenesis, suggests an effective approach for biomarker identification, and provides an important community resource for further analysis of human EVD severity.
Sources: Link 1, Link 2