Adult body cells in tissues cannot divide. With this, DNA does not change or develop especially DNA found in the heart, brain and liver. Scientists have discovered a way to enter the cell and modify the DNA to prevent previously incurable diseases. The technique, known as HITI, was based on the famous CRISPR gene-editing technique. With this, they can insert DNA at a target location into the non-dividing cells that make up the majority of adult organs and tissues.
The researchers used the technique on rats born with a genetic disease called retinitis pigmentosa, which affects about one in 4,000 people in the UK. Researchers are now using this mechanism to correct gene defects. Clinical trials are a long way off because the CRISPR proteins may cut DNA at other sites that may have untoward effects.'